InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GCNT1

Summary

InnateDB Gene

IDBG-72025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCNT1

Gene Name

glucosaminyl (N-acetyl) transferase 1, core 2

Synonyms

C2GNT; C2GNT-L; C2GNT1; G6NT; NACGT2; NAGCT2

Species

Homo sapiens

Ensembl Gene

ENSG00000187210

Encoded Proteins

IDBP-72027

glucosaminyl (N-acetyl) transferase 1, core 2

IDBP-373280

glucosaminyl (N-acetyl) transferase 1, core 2

IDBP-373285

glucosaminyl (N-acetyl) transferase 1, core 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:76419850-76507416

Strand

Forward strand

Band

q21.13

Transcripts

ENST00000376730	ENSP00000365920
ENST00000442371	ENSP00000415454
ENST00000444201	ENSP00000390703
ENST00000488136
ENST00000480311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0005515	protein binding
GO:0008375	acetylglucosaminyltransferase activity

Biological Process

GO:0009101	glycoprotein biosynthetic process
GO:0016266	O-glycan processing
GO:0032868	response to insulin
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048729	tissue morphogenesis
GO:0050901	leukocyte tethering or rolling
GO:0060352	cell adhesion molecule production
GO:0060993	kidney morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031985	Golgi cisterna

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038843

View Gene Order

ENSBTAG00000012757

Not yet available

Pathways

NETPATH

REACTOME

REACT_115606

O-linked glycosylation of mucins pathway

REACT_22161

Post-translational protein modification pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00512

Mucin type O-Glycan biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

Q02742

TrEMBL

UniProt Splice Variant

Entrez Gene

2650

UniGene

Hs.521568 Hs.601628

RefSeq

NM_001097633 NM_001097635 NM_001097636 XM_006717052 NM_001097634 NM_001490

HUGO

HGNC:4203

OMIM

600391

CCDS

CCDS6653

HPRD

02669

IMGT

EMBL

AL161626 BC074885 BC074886 BC109101 BC109102 CH471089 L41415 M97347

GenPept

AAA35919 AAA96661 AAH74885 AAH74886 AAI09102 AAI09103 CAI39746 EAW62580

RNA Seq Atlas

2650