InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCNT1

Summary

InnateDB Protein

IDBP-373285.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCNT1

Protein Name

glucosaminyl (N-acetyl) transferase 1, core 2

Synonyms

C2GNT; C2GNT-L; C2GNT1; G6NT; NACGT2; NAGCT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000390703

InnateDB Gene

IDBG-72025 (GCNT1)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O- glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. {ECO:0000269PubMed:23027862}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:23027862}; Single-pass type II membrane protein {ECO:0000269PubMed:23027862}. Note=Also detected in the trans-Golgi network.

Disease Associations

Tissue Specificity

Highly expressed in activated T-lymphocytes and myeloid cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0005515	protein binding
GO:0008375	acetylglucosaminyltransferase activity

Biological Process

GO:0009101	glycoprotein biosynthetic process
GO:0016266	O-glycan processing
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0050901	leukocyte tethering or rolling
GO:0060352	cell adhesion molecule production