Version 5.4
Homo sapiens Gene: NNMT
Summary
InnateDB Gene IDBG-72066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NNMT
Gene Name nicotinamide N-methyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166741
Encoded Proteins
IDBP-72068
nicotinamide N-methyltransferase
IDBP-583242
nicotinamide N-methyltransferase
IDBP-602284
nicotinamide N-methyltransferase
IDBP-585585
nicotinamide N-methyltransferase
IDBP-600167
nicotinamide N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:114257787-114313285
Strand Forward strand
Band q23.2
Transcripts
ENST00000299964 ENSP00000299964
ENST00000535185
ENST00000535401 ENSP00000441434
ENST00000541090
ENST00000546313
ENST00000541754 ENSP00000445680
ENST00000542647 ENSP00000445994
ENST00000545255 ENSP00000445248
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0010243 response to organonitrogen compound
GO:0031100 organ regeneration
GO:0032259 methylation
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032271
View Gene Order
Pathways
NETPATH
REACTOME
REACT_6946
Methylation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00760
Nicotinate and nicotinamide metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503911 Hs.623245 Hs.731965
RefSeq NM_006169
HUGO
OMIM
CCDS CCDS8368
HPRD 02478
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca