InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NNMT

Summary

InnateDB Protein

IDBP-583242.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NNMT

Protein Name

nicotinamide N-methyltransferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000441434

InnateDB Gene

IDBG-72066 (NNMT)

Protein Structure

UniProt Annotation

Function

Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008112	nicotinamide N-methyltransferase activity
GO:0008168	methyltransferase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0010243	response to organonitrogen compound
GO:0031100	organ regeneration
GO:0032259	methylation
GO:0042493	response to drug
GO:0044281	small molecule metabolic process