Version 5.4
Homo sapiens Gene: EPB41L1
Summary
InnateDB Gene IDBG-72099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPB41L1
Gene Name erythrocyte membrane protein band 4.1-like 1
Synonyms 4.1N; MRD11
Species Homo sapiens
Ensembl Gene ENSG00000088367
Encoded Proteins
IDBP-72101
erythrocyte membrane protein band 4.1-like 1
IDBP-72103
erythrocyte membrane protein band 4.1-like 1
IDBP-72107
erythrocyte membrane protein band 4.1-like 1
IDBP-72109
erythrocyte membrane protein band 4.1-like 1
IDBP-72111
erythrocyte membrane protein band 4.1-like 1
IDBP-72113
erythrocyte membrane protein band 4.1-like 1
IDBP-293575
erythrocyte membrane protein band 4.1-like 1
IDBP-374182
erythrocyte membrane protein band 4.1-like 1
IDBP-374189
erythrocyte membrane protein band 4.1-like 1
IDBP-374204
erythrocyte membrane protein band 4.1-like 1
IDBP-374208
erythrocyte membrane protein band 4.1-like 1
IDBP-374209
erythrocyte membrane protein band 4.1-like 1
IDBP-374211
erythrocyte membrane protein band 4.1-like 1
IDBP-374226
erythrocyte membrane protein band 4.1-like 1
IDBP-374230
erythrocyte membrane protein band 4.1-like 1
IDBP-374234
erythrocyte membrane protein band 4.1-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The protein encoded by this gene is a neuronally-enriched protein that is structurally similar to EPB41. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:36091504-36232799
Strand Forward strand
Band q11.23
Transcripts
ENST00000202028 ENSP00000202028
ENST00000373950 ENSP00000363061
ENST00000373946 ENSP00000363057
ENST00000338074 ENSP00000337168
ENST00000373945 ENSP00000363056
ENST00000373941 ENSP00000363052
ENST00000406771 ENSP00000385244
ENST00000432589 ENSP00000393106
ENST00000430276 ENSP00000404341
ENST00000452261 ENSP00000413262
ENST00000447825 ENSP00000396366
ENST00000441639 ENSP00000399214
ENST00000427533 ENSP00000408877
ENST00000451082 ENSP00000406464
ENST00000454226 ENSP00000388281
ENST00000432603 ENSP00000390262
ENST00000479336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0007268 synaptic transmission
GO:0030866 cortical actin cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0019898 extrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027624
View Gene Order
ENSBTAG00000001640
Not yet available
Pathways
NETPATH
REACTOME
REACT_18307
Trafficking of AMPA receptors pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437422 Hs.695199
RefSeq NM_001258329 NM_001258330 NM_001258331 NM_012156 NM_177996 XM_005260319 XM_005260323 XM_006723736 XM_006723737 XM_006723738 XM_006723739 XM_006723741
HUGO
OMIM
CCDS CCDS13271 CCDS13272 CCDS58771
HPRD 04193
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca