InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNA14

Summary

InnateDB Gene

IDBG-72390.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNA14

Gene Name

guanine nucleotide binding protein (G protein), alpha 14

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000156049

Encoded Proteins

IDBP-72392

guanine nucleotide binding protein (G protein), alpha 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:77423079-77648307

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000341700	ENSP00000365807
ENST00000464095

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway