InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNA14

Summary

InnateDB Protein

IDBP-72392.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNA14

Protein Name

guanine nucleotide binding protein (G protein), alpha 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365807

InnateDB Gene

IDBG-72390 (GNA14)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000654 G-protein alpha subunit, group Q
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00442
PR00318
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt