Version 5.4
Homo sapiens Gene: STAM2
Summary
InnateDB Gene IDBG-72415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAM2
Gene Name signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms Hbp; STAM2A; STAM2B
Species Homo sapiens
Ensembl Gene ENSG00000115145
Encoded Proteins
IDBP-72417
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:152116801-152175992
Strand Reverse strand
Band q23.3
Transcripts
ENST00000263904 ENSP00000263904
ENST00000489389
ENST00000482997
ENST00000463854
ENST00000465460
ENST00000494589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 55 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0016197 endosomal transport
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000055371
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_14
IL2 pathway
REACTOME
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt O75886
TrEMBL
UniProt Splice Variant
Entrez Gene 10254
UniGene Hs.17200 Hs.604700
RefSeq NM_005843
HUGO HGNC:11358
OMIM 606244
CCDS CCDS2196
HPRD 05876
IMGT
EMBL AC079790 AF042273 AF042274 AK292265 AK292847 AL133600 BC028740 CH471058
GenPept AAC63963 AAC63964 AAH28740 AAY14712 BAF84954 BAF85536 CAB63735 EAX11490 EAX11492
RNA Seq Atlas 10254

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca