Version 5.4
Mus musculus Gene: Stam2
Summary
InnateDB Gene IDBG-171042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stam2
Gene Name signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms 1200004O12Rik; 5730456G07Rik; BB145015; Hbp
Species Mus musculus
Ensembl Gene ENSMUSG00000055371
Encoded Proteins
IDBP-171044
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
IDBP-535418
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
IDBP-532829
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
IDBP-534502
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115145:
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:52691664-52742281
Strand Reverse strand
Band C1.1
Transcripts
ENSMUST00000102759 ENSMUSP00000099820
ENSMUST00000127316 ENSMUSP00000121898
ENSMUST00000150582
ENSMUST00000155516 ENSMUSP00000119203
ENSMUST00000138290 ENSMUSP00000114620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000115145
View Gene Order
Pathways
NETPATH
REACTOME
REACT_203917
EGFR downregulation pathway
REACT_189085
Disease pathway
REACT_209837
Membrane Trafficking pathway
REACT_198518
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_242976
Signaling by EGFR pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
mmu04630
Jak-STAT signaling pathway pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_14
IL2 pathway
REACTOME
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.263639 Mm.393555
RefSeq NM_019667 XM_006498198 XM_006498199
OMIM
CCDS CCDS16037
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca