InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALYREF

Summary

InnateDB Gene

IDBG-72719.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALYREF

Gene Name

Aly/REF export factor

Synonyms

ALY; ALY/REF; BEF; REF; THOC4

Species

Homo sapiens

Ensembl Gene

ENSG00000183684

Encoded Proteins

IDBP-485638

THO complex 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81887844-81891586

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000505490	ENSP00000421592
ENST00000504015
ENST00000512673
ENST00000511412

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	107 [view]
Protein-Protein	106 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000018	regulation of DNA recombination
GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0031297	replication fork processing
GO:0032786	positive regulation of DNA-templated transcription, elongation
GO:0046784	intronless viral mRNA export from host nucleus

Cellular Component

GO:0000346	transcription export complex
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome