Version 5.4
Bos taurus Gene: ALYREF
Summary
InnateDB Gene IDBG-642357.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALYREF
Gene Name THO complex subunit 4
Synonyms THOC4
Species Bos taurus
Ensembl Gene ENSBTAG00000008498
Encoded Proteins
IDBP-694803
THO complex subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183684:
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51609699-51613483
Strand Forward strand
Band
Transcripts
ENSBTAT00000011202 ENSBTAP00000011202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000018 regulation of DNA recombination
GO:0001649 osteoblast differentiation
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0006810 transport
GO:0008380 RNA splicing
GO:0031297 replication fork processing
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0046784 intronless viral mRNA export from host nucleus
GO:0051028 mRNA transport
Cellular Component
GO:0000346 transcription export complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000183684
View Gene Order
ENSMUSG00000025134
View Gene Order
Pathways
NETPATH
REACTOME
REACT_209718
RNA Polymerase II Transcription pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_224602
Transport of Mature Transcript to Cytoplasm pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_207634
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_226022
Gene Expression pathway
REACT_220982
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_219885
Transport of the SLBP independent Mature mRNA pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_213547
Transport of the SLBP Dependant Mature mRNA pathway
REACT_210287
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_424
Transport of the SLBP independent Mature mRNA pathway
REACT_405
Transport of the SLBP Dependant Mature mRNA pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_240247
mRNA 3'-end processing pathway
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_249110
mRNA Splicing pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_212343
Transport of the SLBP independent Mature mRNA pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_244199
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_250734
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_232353
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_239127
Transport of the SLBP Dependant Mature mRNA pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
mmu03040
Spliceosome pathway
mmu03013
RNA transport pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q3T0I4
TrEMBL
UniProt Splice Variant
Entrez Gene 537706
UniGene Bt.48992
RefSeq NM_001035417
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102384
GenPept AAI02385
RNA Seq Atlas 537706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca