Version 5.4
Homo sapiens Gene: GPD2
Summary
InnateDB Gene IDBG-72772.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPD2
Gene Name glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Synonyms GDH2; GPDM; mGPDH
Species Homo sapiens
Ensembl Gene ENSG00000115159
Encoded Proteins
IDBP-72774
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-294001
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-294002
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-293996
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-386714
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-386718
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-386720
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-386721
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
IDBP-596550
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:156435290-156613735
Strand Forward strand
Band q24.1
Transcripts
ENST00000310454 ENSP00000308610
ENST00000409861 ENSP00000386626
ENST00000409125 ENSP00000386484
ENST00000409674 ENSP00000386425
ENST00000415049 ENSP00000412621
ENST00000438166 ENSP00000409708
ENST00000416888 ENSP00000387475
ENST00000430992 ENSP00000408522
ENST00000495851
ENST00000464846
ENST00000492005
ENST00000496190
ENST00000540309 ENSP00000440892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004368 glycerol-3-phosphate dehydrogenase activity
GO:0005509 calcium ion binding
GO:0016491 oxidoreductase activity
GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
Biological Process
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0019563 glycerol catabolic process
GO:0035264 multicellular organism growth
GO:0043010 camera-type eye development
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0009331 glycerol-3-phosphate dehydrogenase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026827
View Gene Order
ENSBTAG00000009770
Not yet available
Pathways
NETPATH
REACTOME
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.148266 Hs.512382 Hs.618745 Hs.665979 Hs.735478
RefSeq NM_000408 NM_001083112 XM_005246469 XM_005246470
HUGO
OMIM
CCDS CCDS2202
HPRD 00715
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca