Version 5.4
Homo sapiens Gene: EGLN2
Summary
InnateDB Gene IDBG-728297.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGLN2
Gene Name egl nine homolog 2 (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000269858
Encoded Proteins
IDBP-52266
egl nine homolog 2 (C. elegans)
IDBP-294795
egl nine homolog 2 (C. elegans)
IDBP-760985
IDBP-761864
IDBP-763194
IDBP-760817
IDBP-763707
IDBP-766013
IDBP-765031
IDBP-763495
IDBP-762655
IDBP-762735
IDBP-765583
IDBP-763908
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24145445
Regulation of IL1B-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways in a manner that is dependent upon the combinatorial blockade of both EGLN2 and HIF1AN.
Entrez Gene
Summary The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40798996-40808433
Strand Forward strand
Band q13.2
Transcripts
ENST00000303961 ENSP00000307080
ENST00000406058 ENSP00000385253
ENST00000593477
ENST00000593445
ENST00000593525 ENSP00000469272
ENST00000595051 ENSP00000471740
ENST00000594140 ENSP00000472414
ENST00000593397 ENSP00000472146
ENST00000597746 ENSP00000472991
ENST00000595621 ENSP00000471944
ENST00000601733 ENSP00000469323
ENST00000593972 ENSP00000471546
ENST00000602166
ENST00000598654 ENSP00000471568
ENST00000599579
ENST00000593726 ENSP00000469686
ENST00000594380 ENSP00000470968
ENST00000596517 ENSP00000472870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826 oxygen sensor activity
GO:0031418 L-ascorbic acid binding
GO:0031543 peptidyl-proline dioxygenase activity
GO:0031545 peptidyl-proline 4-dioxygenase activity
Biological Process
GO:0001558 regulation of cell growth
GO:0001666 response to hypoxia
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0043523 regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045454 cell redox homeostasis
GO:0045732 positive regulation of protein catabolic process
GO:0055114 oxidation-reduction process
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_120956
Cellular responses to stress pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_121311
Cellular response to hypoxia pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515417
RefSeq NM_053046 NM_080732
HUGO
OMIM
CCDS CCDS12567
HPRD 06970
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca