InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EGLN2

Summary

InnateDB Protein

IDBP-763194.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGLN2

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000472414

InnateDB Gene

IDBG-728297 (EGLN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826	oxygen sensor activity
GO:0031418	L-ascorbic acid binding
GO:0031545	peptidyl-proline 4-dioxygenase activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001666	response to hypoxia
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0043523	regulation of neuron apoptotic process
GO:0045454	cell redox homeostasis
GO:0045732	positive regulation of protein catabolic process
GO:0055114	oxidation-reduction process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia