Version 5.4
Homo sapiens Gene: ZNF274
Summary
InnateDB Gene IDBG-73036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF274
Gene Name zinc finger protein 274
Synonyms HFB101; ZF2; ZKSCAN19; ZSCAN51
Species Homo sapiens
Ensembl Gene ENSG00000171606
Encoded Proteins
IDBP-73038
zinc finger protein 274
IDBP-73040
zinc finger protein 274
IDBP-385661
zinc finger protein 274
IDBP-766059
IDBP-765262
IDBP-806728
zinc finger protein 274
IDBP-806732
zinc finger protein 274
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:58183029-58213562
Strand Forward strand
Band q13.43
Transcripts
ENST00000326804 ENSP00000321209
ENST00000345813 ENSP00000321187
ENST00000424679 ENSP00000409872
ENST00000597528 ENSP00000469546
ENST00000600704
ENST00000594248
ENST00000595146
ENST00000594839 ENSP00000469427
ENST00000601995
ENST00000621145
ENST00000619307
ENST00000617501 ENSP00000484810
ENST00000615675
ENST00000610905 ENSP00000478533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001278734 NM_001278735 NM_016324 NM_016325 NM_133502
HUGO
OMIM
CCDS CCDS74473 CCDS74474 CCDS74475 CCDS74476
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca