InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF274

Summary

InnateDB Protein

IDBP-73038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF274

Protein Name

zinc finger protein 274

Synonyms

HFB101; ZF2; ZKSCAN19; ZSCAN51;

Species

Homo sapiens

Ensembl Protein

ENSP00000321209

InnateDB Gene

IDBG-73036 (ZNF274)

Protein Structure

UniProt Annotation

Function

Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. {ECO:0000269PubMed:10777669}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000269PubMed:10777669}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

InterPro

IPR001909 Krueppel-associated box
IPR003309 Transcription regulator SCAN
IPR007087 Zinc finger, C2H2
IPR008916 Retrovirus capsid, C-terminal
IPR015880 Zinc finger, C2H2-like

PFAM

PF01352
PF02023
PF00096

PRINTS

PIRSF

SMART

SM00349
SM00431
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96GC6