InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSNK1D

Summary

InnateDB Gene

IDBG-73381.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK1D

Gene Name

casein kinase 1, delta

Synonyms

ASPS; CKIdelta; FASPS2; HCKID

Species

Homo sapiens

Ensembl Gene

ENSG00000141551

Encoded Proteins

IDBP-73383

casein kinase 1, delta

IDBP-73385

casein kinase 1, delta

IDBP-232919

casein kinase 1, delta

IDBP-245870

casein kinase 1, delta

IDBP-293245

casein kinase 1, delta

IDBP-762957

IDBP-761676

IDBP-761632

IDBP-761587

IDBP-761902

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:82239023-82273731

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000314028	ENSP00000324464
ENST00000269361	ENSP00000269361
ENST00000398519	ENSP00000381531
ENST00000392334	ENSP00000376146
ENST00000403276	ENSP00000385769
ENST00000579316
ENST00000580784	ENSP00000463906
ENST00000584377
ENST00000580565
ENST00000578194
ENST00000578904
ENST00000577578
ENST00000578501
ENST00000582844
ENST00000580061
ENST00000581737
ENST00000580446	ENSP00000463757
ENST00000581655
ENST00000581241
ENST00000585026	ENSP00000462144
ENST00000581108
ENST00000584672	ENSP00000462079
ENST00000579308
ENST00000584472
ENST00000584913
ENST00000581660	ENSP00000464551

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042277	peptide binding
GO:0050321	tau-protein kinase activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001934	positive regulation of protein phosphorylation
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0016055	Wnt signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0051225	spindle assembly
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0048471	perinuclear region of cytoplasm