InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHMP2A

Summary

InnateDB Gene

IDBG-73495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHMP2A

Gene Name

charged multivesicular body protein 2A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000130724

Encoded Proteins

IDBP-73497

charged multivesicular body protein 2A

IDBP-764659

IDBP-763160

IDBP-760790

IDBP-765638

IDBP-765577

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:58551566-58555124

Strand

Reverse strand

Band

q13.43

Transcripts

ENST00000312547	ENSP00000310440
ENST00000600804
ENST00000600118	ENSP00000469240
ENST00000601220	ENSP00000472680
ENST00000596708	ENSP00000471961
ENST00000597209
ENST00000600006	ENSP00000472097
ENST00000597848	ENSP00000469453

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0007034	vacuolar transport
GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0045184	establishment of protein localization
GO:0050792	regulation of viral process
GO:0061024	membrane organization
GO:1902188	positive regulation of viral release from host cell

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033916

View Gene Order

ENSBTAG00000013882

Not yet available

Pathways

NETPATH

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_27258

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_116125

Disease pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

M0QXX8

UniProt Splice Variant

Entrez Gene

27243

UniGene

RefSeq

NM_014453 NM_198426 XM_005258746 XM_005258747

HUGO

HGNC:30216

OMIM

610893

CCDS

CCDS12986

HPRD

12520

IMGT

EMBL

AC016630

GenPept

RNA Seq Atlas

27243