InnateDB Protein
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IDBP-73497.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHMP2A
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Protein Name
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charged multivesicular body protein 2A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310440
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InnateDB Gene
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IDBG-73495 (CHMP2A)
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Protein Structure
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Function |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV- 1 p6- and p9-dependent virus release. {ECO:0000269PubMed:14505570, ECO:0000269PubMed:14519844}.
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Subcellular Localization |
Late endosome membrane {ECO:0000269PubMed:16730941, ECO:0000269PubMed:17853893}; Peripheral membrane protein {ECO:0000269PubMed:16730941, ECO:0000269PubMed:17853893}; Cytoplasmic side {ECO:0000269PubMed:16730941, ECO:0000269PubMed:17853893}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005024
Snf7
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PFAM |
PF03357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43633
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PhosphoSite |
PhosphoSite-O43633
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TrEMBL |
M0R1L7
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UniProt Splice Variant |
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Entrez Gene |
27243
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UniGene |
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RefSeq |
NP_055268
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HUGO |
HGNC:30216
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OMIM |
610893
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CCDS |
CCDS12986
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HPRD |
12520
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IMGT |
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EMBL |
AC016630
AF042384
AJ277113
AK311974
AY364248
BC002502
BT007298
CH471135
CR457002
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GenPept |
AAC00005
AAH02502
AAP35962
AAQ76807
BAG34913
CAC14310
CAG33283
EAW72609
EAW72610
EAW72611
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