Version 5.4
Homo sapiens Gene: VSIG4
Summary
InnateDB Gene IDBG-73541.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VSIG4
Gene Name V-set and immunoglobulin domain containing 4
Synonyms CRIg; Z39IG
Species Homo sapiens
Ensembl Gene ENSG00000155659
Encoded Proteins
IDBP-73543
V-set and immunoglobulin domain containing 4
IDBP-374344
V-set and immunoglobulin domain containing 4
IDBP-374353
V-set and immunoglobulin domain containing 4
IDBP-374360
V-set and immunoglobulin domain containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:66021738-66040125
Strand Reverse strand
Band q12
Transcripts
ENST00000374737 ENSP00000363869
ENST00000427538 ENSP00000393108
ENST00000412866 ENSP00000394143
ENST00000455586 ENSP00000411581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006957 complement activation, alternative pathway
GO:0032703 negative regulation of interleukin-2 production
GO:0042130 negative regulation of T cell proliferation
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044206
View Gene Order
ENSBTAG00000015769
Not yet available
Cross-References
SwissProt Q9Y279
TrEMBL
UniProt Splice Variant
Entrez Gene 11326
UniGene Hs.8904
RefSeq NM_001100431 NM_001184830 NM_001184831 NM_001257403 NM_007268
HUGO HGNC:17032
OMIM 300353
CCDS CCDS48132 CCDS14383 CCDS55435
HPRD 02286
IMGT
EMBL AJ132502 AL034397 AY358341 BC010525 CR607860
GenPept AAH10525 AAQ88707 CAB46921 CAB51536
RNA Seq Atlas 11326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca