Version 5.4
Homo sapiens Gene: FOXK2
Summary
InnateDB Gene IDBG-73636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXK2
Gene Name forkhead box K2
Synonyms ILF; ILF-1; ILF1
Species Homo sapiens
Ensembl Gene ENSG00000141568
Encoded Proteins
IDBP-73640
forkhead box K2
IDBP-592544
forkhead box K2
IDBP-595078
forkhead box K2
IDBP-603775
forkhead box K2
IDBP-757865
IDBP-811691
forkhead box K2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:82519713-82644662
Strand Forward strand
Band q25.3
Transcripts
ENST00000335255 ENSP00000335677
ENST00000473637 ENSP00000436108
ENST00000527313
ENST00000531030 ENSP00000433167
ENST00000526383 ENSP00000432663
ENST00000529652
ENST00000574694
ENST00000571989
ENST00000571160
ENST00000570585
ENST00000575578 ENSP00000461540
ENST00000624186
ENST00000622867 ENSP00000481132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039275
View Gene Order
ENSBTAG00000003687
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591140 Hs.625927 Hs.629032 Hs.645166 Hs.713802 Hs.718313 Hs.735862
RefSeq NM_004514
HUGO
OMIM
CCDS CCDS11813
HPRD 00982
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca