InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXK2

Summary

InnateDB Protein

IDBP-73640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXK2

Protein Name

forkhead box K2

Synonyms

ILF; ILF-1; ILF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000335677

InnateDB Gene

IDBG-73636 (FOXK2)

Protein Structure

UniProt Annotation

Function

Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements. {ECO:0000269PubMed:1339390, ECO:0000269PubMed:1909027}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in both lymphoid and non-lymphoid cells. {ECO:0000269PubMed:1339390}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter