InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP5L

Summary

InnateDB Gene

IDBG-73678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5L

Gene Name

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G

Synonyms

ATP5JG

Species

Homo sapiens

Ensembl Gene

ENSG00000167283

Encoded Proteins

IDBP-73680

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G

IDBP-599462

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118401154-118431496

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000300688	ENSP00000300688
ENST00000529790
ENST00000529770
ENST00000533172
ENST00000524422	ENSP00000434865
ENST00000529460
ENST00000534385
ENST00000527186

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006200	ATP catabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038717

View Gene Order

ENSBTAG00000007332

Not yet available

Pathways

NETPATH

REACTOME

REACT_6759

Formation of ATP by chemiosmotic coupling pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

INOH

PID NCI

Cross-References

SwissProt

O75964

TrEMBL

UniProt Splice Variant

Entrez Gene

10632

UniGene

RefSeq

NM_006476

HUGO

HGNC:14247

OMIM

CCDS

CCDS8397

HPRD

09815

IMGT

EMBL

AF070655 AF087846 AF092124 AK289568 AL050277 BC015128 BC070165 CH471065 CR533494 CR542211

GenPept

AAC61597 AAD20961 AAH15128 AAH70165 AAP97159 BAF82257 CAB43378 CAG38525 CAG47007 EAW67376

RNA Seq Atlas

10632