Homo sapiens Gene: ZFP57

Summary
InnateDB Gene IDBG-73686.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol ZFP57
Gene Name zinc finger protein 57 homolog (mouse)
Synonyms bA145L22; bA145L22.2; C6orf40; TNDM1; ZNF698
Species Homo sapiens
Ensembl Gene ENSG00000204644
Encoded Proteins
IDBP-73688 zinc finger protein 57 homolog (mouse)
IDBP-73690 zinc finger protein 57 homolog (mouse)
IDBP-484447 zinc finger protein 57 homolog (mouse)
Entrez Gene
Summary The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6: 29640169-29648887
Strand Reverse strand
Band p22.1
Transcripts
ENST00000376883  ENSP00000366080
ENST00000376881  ENSP00000366078
ENST00000488757  ENSP00000418259
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein‑Protein  4
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-dependent
GO:0006355 regulation of transcription, DNA-dependent
GO:0007422 peripheral nervous system development
GO:0043045 DNA methylation involved in embryo development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000036036 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000017836 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NU63 
TrEMBL
UniProt Splice Variant
Entrez Gene 346171 
UniGene Hs.156326
RefSeq NM_001109809 
HUGO 18791 
OMIM 612192
CCDS CCDS43436 
HPRD
IMGT
EMBL AL050328 AL645936 AL669813 AL929591 BC157878 BX120002 BX927250 CR388408 CR759766 CR936483
GenPept AAI57879  CAB89275  CAI17624  CAI18028  CAI41919  CAI95569  CAQ06621  CAQ08216  CAQ10094  CAQ10717 
ImmGen ZFP57 (murine) 
RNA Seq Atlas 346171