Version 5.4
Homo sapiens Gene: GCA
Summary
InnateDB Gene IDBG-73781.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCA
Gene Name grancalcin, EF-hand calcium binding protein
Synonyms GCL
Species Homo sapiens
Ensembl Gene ENSG00000115271
Encoded Proteins
IDBP-73783
grancalcin, EF-hand calcium binding protein
IDBP-387039
grancalcin, EF-hand calcium binding protein
IDBP-387040
grancalcin, EF-hand calcium binding protein
IDBP-387042
grancalcin, EF-hand calcium binding protein
IDBP-387043
grancalcin, EF-hand calcium binding protein
IDBP-387047
grancalcin, EF-hand calcium binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:162318840-162371595
Strand Forward strand
Band q24.2
Transcripts
ENST00000233612 ENSP00000233612
ENST00000446271 ENSP00000393218
ENST00000429691 ENSP00000412899
ENST00000437150 ENSP00000394842
ENST00000453113 ENSP00000403805
ENST00000414723 ENSP00000408620
ENST00000473240
ENST00000481161
ENST00000487445
ENST00000479199
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006508 proteolysis
GO:0061025 membrane fusion
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026893
View Gene Order
ENSBTAG00000018446
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.377894 Hs.706006
RefSeq NM_012198 XM_006712398 XM_006712399
HUGO
OMIM
CCDS CCDS2218
HPRD 06122
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca