InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCA

Summary

InnateDB Protein

IDBP-387042.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCA

Protein Name

grancalcin, EF-hand calcium binding protein

Synonyms

GCL;

Species

Homo sapiens

Ensembl Protein

ENSP00000394842

InnateDB Gene

IDBG-73781 (GCA)

Protein Structure

UniProt Annotation

Function

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

Subcellular Localization

Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels.

Disease Associations

Tissue Specificity

Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow. {ECO:0000269PubMed:1737748}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity