InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPN2

Summary

InnateDB Gene

IDBG-73849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPN2

Gene Name

ribophorin II

Synonyms

RIBIIR; RPN-II; RPNII; SWP1

Species

Homo sapiens

Ensembl Gene

ENSG00000118705

Encoded Proteins

IDBP-73851

ribophorin II

IDBP-73855

ribophorin II

IDBP-73861

ribophorin II

IDBP-374603

ribophorin II

IDBP-374634

ribophorin II

IDBP-374636

ribophorin II

IDBP-594472

ribophorin II

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:37178410-37241623

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000237530	ENSP00000237530
ENST00000373632	ENSP00000362735
ENST00000373622	ENSP00000362724
ENST00000456102	ENSP00000399137
ENST00000437329	ENSP00000409580
ENST00000456400	ENSP00000399404
ENST00000462163	ENSP00000435563
ENST00000470352

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0043022	ribosome binding

Biological Process

GO:0006412	translation
GO:0006464	cellular protein modification process
GO:0006487	protein N-linked glycosylation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007568	aging
GO:0010467	gene expression
GO:0018279	protein N-linked glycosylation via asparagine
GO:0042493	response to drug
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027642

View Gene Order

ENSBTAG00000014648

Not yet available

Pathways

NETPATH

REACTOME

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_115902

SRP-dependent cotranslational protein targeting to membrane pathway

REACT_22161

Post-translational protein modification pathway

REACT_1014

Translation pathway

REACT_17015

Metabolism of proteins pathway

REACT_71

Gene Expression pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.370895

RefSeq

NM_001135771 NM_002951

HUGO

OMIM

CCDS

CCDS13291 CCDS46599

HPRD

01609

IMGT

EMBL

GenPept

RNA Seq Atlas