Version 5.4
Homo sapiens Gene: MAFF
Summary
InnateDB Gene IDBG-7398.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAFF
Gene Name v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
Synonyms hMafF; U-MAF
Species Homo sapiens
Ensembl Gene ENSG00000185022
Encoded Proteins
IDBP-7400
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
IDBP-293639
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
IDBP-376464
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
IDBP-376468
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
IDBP-376472
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
IDBP-585840
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
IDBP-584741
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38200767-38216511
Strand Forward strand
Band q13.1
Transcripts
ENST00000338483 ENSP00000345393
ENST00000407965 ENSP00000384094
ENST00000441709 ENSP00000391589
ENST00000417948 ENSP00000416493
ENST00000426621 ENSP00000388882
ENST00000538320 ENSP00000442060
ENST00000538999 ENSP00000441482
ENST00000624676
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007567 parturition
GO:0007596 blood coagulation
GO:0035914 skeletal muscle cell differentiation
GO:0045604 regulation of epidermal cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042622
View Gene Order
ENSBTAG00000021435
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517617 Hs.630450
RefSeq NM_001161572 NM_001161573 NM_001161574 NM_012323
HUGO
OMIM
CCDS CCDS13968 CCDS54528
HPRD 05343
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca