InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAFF

Summary

InnateDB Protein

IDBP-7400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAFF

Protein Name

v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)

Synonyms

hMafF; U-MAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000345393

InnateDB Gene

IDBG-7398 (MAFF)

Protein Structure

UniProt Annotation

Function

Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in the term myometrium and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	26 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007567	parturition
GO:0007596	blood coagulation
GO:0035914	skeletal muscle cell differentiation
GO:0045604	regulation of epidermal cell differentiation