Version 5.4
Homo sapiens Gene: TREH
Summary
InnateDB Gene IDBG-74031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREH
Gene Name trehalase (brush-border membrane glycoprotein)
Synonyms TRE; TREA
Species Homo sapiens
Ensembl Gene ENSG00000118094
Encoded Proteins
IDBP-74033
trehalase (brush-border membrane glycoprotein)
IDBP-234281
trehalase (brush-border membrane glycoprotein)
IDBP-808170
trehalase (brush-border membrane glycoprotein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:118657316-118679690
Strand Reverse strand
Band q23.3
Transcripts
ENST00000264029 ENSP00000264029
ENST00000397925 ENSP00000381020
ENST00000531295
ENST00000527558
ENST00000613915 ENSP00000477923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004555 alpha,alpha-trehalase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process
GO:0009887 organ morphogenesis
GO:0044245 polysaccharide digestion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032098
View Gene Order
ENSBTAG00000016202
Not yet available
Pathways
NETPATH
REACTOME
REACT_9472
Digestion of dietary carbohydrate pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00500
Starch and sucrose metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001301065 NM_007180 XM_005277678
HUGO
OMIM
CCDS CCDS73401 CCDS73402
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca