InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TREH

Summary

InnateDB Protein

IDBP-74033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TREH

Protein Name

trehalase (brush-border membrane glycoprotein)

Synonyms

TRE; TREA;

Species

Homo sapiens

Ensembl Protein

ENSP00000264029

InnateDB Gene

IDBG-74031 (TREH)

Protein Structure

UniProt Annotation

Function

Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Note=Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004555	alpha,alpha-trehalase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005991	trehalose metabolic process
GO:0005993	trehalose catabolic process
GO:0009887	organ morphogenesis
GO:0044245	polysaccharide digestion
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001661 Glycoside hydrolase, family 37
IPR008928 Six-hairpin glycosidase-like

PFAM

PF01204

PRINTS

PR00744

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43280

PhosphoSite

PhosphoSite-O43280

TrEMBL

UniProt Splice Variant

Entrez Gene

11181

UniGene

RefSeq

NP_009111

HUGO

HGNC:12266

OMIM

275360

CCDS

CCDS73402

HPRD

02038

IMGT

EMBL

AB000824 AK223140 AK223143 BC109206 CH471065

GenPept

AAI09207 BAA24381 BAD96860 BAD96863 EAW67409