InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCR5

Summary

InnateDB Gene

IDBG-74047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR5

Gene Name

chemokine (C-X-C motif) receptor 5

Synonyms

BLR1; CD185; MDR15

Species

Homo sapiens

Ensembl Gene

ENSG00000160683

Encoded Proteins

IDBP-74049

chemokine (C-X-C motif) receptor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt\'s lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118883766-118897799

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000292174

ENSP00000292174

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	20 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016494	C-X-C chemokine receptor activity

Biological Process

GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032467	positive regulation of cytokinesis
GO:0042113	B cell activation
GO:0048535	lymph node development
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000047880

View Gene Order

ENSBTAG00000046320

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P32302

TrEMBL

A0N0R2

UniProt Splice Variant

Entrez Gene

643

UniGene

Hs.113916

RefSeq

NM_001716 NM_032966

HUGO

HGNC:1060

OMIM

601613

CCDS

CCDS8402

HPRD

03367

IMGT

EMBL

CH471065 EF064770 EF444957 X68149 X68829

GenPept

ABK41953 ACA05956 CAA48252 CAA48723 EAW67415

RNA Seq Atlas

643