InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCR5

Summary

InnateDB Protein

IDBP-74049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR5

Protein Name

chemokine (C-X-C motif) receptor 5

Synonyms

BLR1; CD185; MDR15;

Species

Homo sapiens

Ensembl Protein

ENSP00000292174

InnateDB Gene

IDBG-74047 (CXCR5)

Protein Structure

UniProt Annotation

Function

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expression in mature B-cells and Burkitt lymphoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	20 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016494	C-X-C chemokine receptor activity

Biological Process

GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032467	positive regulation of cytokinesis
GO:0042113	B cell activation
GO:0048535	lymph node development
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001053 CXC chemokine receptor 5
IPR001277 CXC chemokine receptor 4
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00241
PR00237
PR00564
PR00645

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32302