Version 5.4
Homo sapiens Gene: SLC37A4
Summary
InnateDB Gene IDBG-74181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC37A4
Gene Name solute carrier family 37 (glucose-6-phosphate transporter), member 4
Synonyms G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG-19; TRG19
Species Homo sapiens
Ensembl Gene ENSG00000137700
Encoded Proteins
IDBP-808213
solute carrier family 37 (glucose-6-phosphate transporter), member 4
IDBP-808211
solute carrier family 37 (glucose-6-phosphate transporter), member 4
IDBP-808207
solute carrier family 37 (glucose-6-phosphate transporter), member 4
IDBP-808209
solute carrier family 37 (glucose-6-phosphate transporter), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119024114-119030906
Strand Reverse strand
Band q23.3
Transcripts
ENST00000330775 ENSP00000476242
ENST00000357590 ENSP00000476176
ENST00000525102
ENST00000526275
ENST00000532085
ENST00000527992
ENST00000530407
ENST00000525372
ENST00000524428
ENST00000525039
ENST00000529510
ENST00000532888
ENST00000526626
ENST00000525787
ENST00000534384
ENST00000545985 ENSP00000475241
ENST00000538950 ENSP00000475991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015152 glucose-6-phosphate transmembrane transporter activity
Biological Process
GO:0001780 neutrophil homeostasis
GO:0001816 cytokine production
GO:0002318 myeloid progenitor cell differentiation
GO:0005977 glycogen metabolic process
GO:0006089 lactate metabolic process
GO:0006641 triglyceride metabolic process
GO:0006810 transport
GO:0006874 cellular calcium ion homeostasis
GO:0007584 response to nutrient
GO:0008202 steroid metabolic process
GO:0009749 response to glucose
GO:0014070 response to organic cyclic compound
GO:0015760 glucose-6-phosphate transport
GO:0030593 neutrophil chemotaxis
GO:0032682 negative regulation of chemokine production
GO:0035166 post-embryonic hemopoiesis
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0043085 positive regulation of catalytic activity
GO:0045730 respiratory burst
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.719203
RefSeq NM_001164277 NM_001164278 NM_001164279 NM_001164280 NM_001467
HUGO
OMIM
CCDS
HPRD 04052
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca