Version 5.4
Homo sapiens Gene: AWAT1
Summary
InnateDB Gene IDBG-74273.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AWAT1
Gene Name acyl-CoA wax alcohol acyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204195
Encoded Proteins
IDBP-74275
acyl-CoA wax alcohol acyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:70234655-70240627
Strand Forward strand
Band q13.1
Transcripts
ENST00000374521 ENSP00000363645
ENST00000480702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity
Biological Process
GO:0006629 lipid metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015665
View Gene Order
ENSBTAG00000018839
Not yet available
Cross-References
SwissProt Q58HT5
TrEMBL
UniProt Splice Variant
Entrez Gene 158833
UniGene Hs.407641
RefSeq NM_001013579
HUGO HGNC:23252
OMIM 300924
CCDS CCDS35321
HPRD
IMGT
EMBL AL357752 AY947638 BC039181 BN000155
GenPept AAX48018 CAD89266 CAI41493
RNA Seq Atlas 158833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca