InnateDB Protein
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IDBP-74275.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AWAT1
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Protein Name
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acyl-CoA wax alcohol acyltransferase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363645
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InnateDB Gene
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IDBG-74273 (AWAT1)
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Protein Structure
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Function |
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). {ECO:0000269PubMed:15671038}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis. {ECO:0000269PubMed:15671038}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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GO:0047196
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long-chain-alcohol O-fatty-acyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007130
Diacylglycerol acyltransferase
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PFAM |
PF03982
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q58HT5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
158833
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UniGene |
Hs.407641
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RefSeq |
NP_001013597
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HUGO |
HGNC:23252
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OMIM |
300924
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CCDS |
CCDS35321
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HPRD |
10296
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IMGT |
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EMBL |
AL357752
AY947638
BC039181
BN000155
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GenPept |
AAX48018
CAD89266
CAI41493
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