Version 5.4
Homo sapiens Gene: STK39
Summary
InnateDB Gene IDBG-74276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK39
Gene Name serine threonine kinase 39
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198648
Encoded Proteins
IDBP-74278
serine threonine kinase 39
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:167954020-168248141
Strand Reverse strand
Band q24.3
Transcripts
ENST00000355999 ENSP00000348278
ENST00000487143
ENST00000461000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0035556 intracellular signal transduction
GO:0043268 positive regulation of potassium ion transport
GO:0050727 regulation of inflammatory response
GO:0071476 cellular hypotonic response
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:2000681 negative regulation of rubidium ion transport
GO:2000687 negative regulation of rubidium ion transmembrane transporter activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027030
View Gene Order
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.276271 Hs.714065
RefSeq NM_013233 XM_005246466
HUGO
OMIM
CCDS CCDS42770
HPRD 09627
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca