InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stk39

Summary

InnateDB Gene

IDBG-175590.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk39

Gene Name

serine/threonine kinase 39

Synonyms

AW227544; AW556857; DCHT; RF005; Rnl5; SPAK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027030

Encoded Proteins

IDBP-175592

serine/threonine kinase 39, STE20/SPS1 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198648:
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:68210445-68472268

Strand

Reverse strand

Band

C1.3

Transcripts

ENSMUST00000102715	ENSMUSP00000099776
ENSMUST00000126663
ENSMUST00000134442
ENSMUST00000144457
ENSMUST00000130380
ENSMUST00000139407
ENSMUST00000123781
ENSMUST00000149581

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0043268	positive regulation of potassium ion transport
GO:0050727	regulation of inflammatory response
GO:0071476	cellular hypotonic response
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:2000681	negative regulation of rubidium ion transport
GO:2000687	negative regulation of rubidium ion transmembrane transporter activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000198648

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

tcr_pathway

TCR signaling in na�ve CD4+ T cells

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.198414

RefSeq

NM_016866

OMIM

CCDS

CCDS16084

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas