InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCB11

Summary

InnateDB Gene

IDBG-74352.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCB11

Gene Name

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Synonyms

ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP

Species

Homo sapiens

Ensembl Gene

ENSG00000073734

Encoded Proteins

IDBP-74354

ATP-binding cassette, sub-family B (MDR/TAP), member 11

IDBP-387309

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:168922938-169031322

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000263817	ENSP00000263817
ENST00000439188	ENSP00000416058
ENST00000478354

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	4 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0008554	sodium-exporting ATPase activity, phosphorylative mechanism
GO:0015126	canalicular bile acid transmembrane transporter activity
GO:0015432	bile acid-exporting ATPase activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006699	bile acid biosynthetic process
GO:0006810	transport
GO:0008206	bile acid metabolic process
GO:0015721	bile acid and bile salt transport
GO:0015722	canalicular bile acid transport
GO:0035725	sodium ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027048

View Gene Order

ENSBTAG00000026885

Not yet available

Pathways

NETPATH

REACTOME

REACT_11041

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway

REACT_11054

Synthesis of bile acids and bile salts pathway

REACT_11042

Recycling of bile acids and salts pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_11040

Bile acid and bile salt metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa02010

ABC transporters pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.658439

RefSeq

NM_003742 XM_006712817 XM_006712818

HUGO

OMIM

CCDS

CCDS46444

HPRD

04436

IMGT

EMBL

GenPept

RNA Seq Atlas