InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcb11

Summary

InnateDB Gene

IDBG-176110.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcb11

Gene Name

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Synonyms

ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027048

Encoded Proteins

IDBP-176112

ATP-binding cassette, sub-family B (MDR/TAP), member 11

IDBP-176116

ATP-binding cassette, sub-family B (MDR/TAP), member 11

IDBP-719178

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:69238282-69342616

Strand

Reverse strand

Band

Transcripts

ENSMUST00000102710	ENSMUSP00000099771
ENSMUST00000102709	ENSMUSP00000099770
ENSMUST00000133663
ENSMUST00000180142	ENSMUSP00000137017

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0015126	canalicular bile acid transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015722	canalicular bile acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus
GO:0070062	extracellular vesicular exosome