Version 5.4
Homo sapiens Gene: PDZD3
Summary
InnateDB Gene IDBG-74360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDZD3
Gene Name PDZ domain containing 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172367
Encoded Proteins
IDBP-74362
PDZ domain containing 3
IDBP-74364
PDZ domain containing 3
IDBP-584071
PDZ domain containing 3
IDBP-586748
PDZ domain containing 3
IDBP-603539
PDZ domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119185457-119190223
Strand Forward strand
Band q23.3
Transcripts
ENST00000322712 ENSP00000327107
ENST00000355547 ENSP00000347742
ENST00000527308
ENST00000526279
ENST00000527951
ENST00000525131 ENSP00000434559
ENST00000534790
ENST00000529098
ENST00000527028
ENST00000531114 ENSP00000431164
ENST00000533688 ENSP00000434264
ENST00000526836
ENST00000528730
ENST00000529573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008200 ion channel inhibitor activity
GO:0030251 guanylate cyclase inhibitor activity
Biological Process
GO:0006811 ion transport
GO:0006833 water transport
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0009636 response to toxic substance
GO:0019934 cGMP-mediated signaling
GO:0030827 negative regulation of cGMP biosynthetic process
GO:0031283 negative regulation of guanylate cyclase activity
Cellular Component
GO:0005829 cytosol
GO:0005903 brush border
GO:0035003 subapical complex
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032105
View Gene Order
ENSBTAG00000012507
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.374726
RefSeq NM_001168468 NM_024791 XM_006718914
HUGO
OMIM
CCDS CCDS53719 CCDS8417
HPRD 06191
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca