InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDZD3

Summary

InnateDB Protein

IDBP-586748.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDZD3

Protein Name

PDZ domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000431164

InnateDB Gene

IDBG-74360 (PDZD3)

Protein Structure

UniProt Annotation

Function

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. {ECO:0000269PubMed:11950846, ECO:0000269PubMed:19088451}.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells.

Disease Associations

Tissue Specificity

Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. {ECO:0000269PubMed:11950846}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008200	ion channel inhibitor activity
GO:0030251	guanylate cyclase inhibitor activity

Biological Process

GO:0006811	ion transport
GO:0006833	water transport
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0009636	response to toxic substance
GO:0019934	cGMP-mediated signaling
GO:0030827	negative regulation of cGMP biosynthetic process
GO:0031283	negative regulation of guanylate cyclase activity