Version 5.4
Homo sapiens Gene: PRKG1
Summary
InnateDB Gene IDBG-74547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKG1
Gene Name protein kinase, cGMP-dependent, type I
Synonyms 1; AAT8; cGK; cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; PKG; PRKG1B; PRKGR1B
Species Homo sapiens
Ensembl Gene ENSG00000185532
Encoded Proteins
IDBP-74549
protein kinase, cGMP-dependent, type I
IDBP-74553
protein kinase, cGMP-dependent, type I
IDBP-74555
protein kinase, cGMP-dependent, type I
IDBP-74557
protein kinase, cGMP-dependent, type I
IDBP-293256
protein kinase, cGMP-dependent, type I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:50991358-52298350
Strand Forward strand
Band q11.23
Transcripts
ENST00000373985 ENSP00000363097
ENST00000373980 ENSP00000363092
ENST00000373976 ENSP00000363087
ENST00000373975 ENSP00000363086
ENST00000401604 ENSP00000384200
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030553 cGMP binding
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0016358 dendrite development
GO:0019934 cGMP-mediated signaling
GO:0030036 actin cytoskeleton organization
GO:0030900 forebrain development
GO:0043087 regulation of GTPase activity
GO:0045986 negative regulation of smooth muscle contraction
GO:0060087 relaxation of vascular smooth muscle
GO:0090331 negative regulation of platelet aggregation
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052920
View Gene Order
ENSBTAG00000018404
Not yet available
Pathways
NETPATH
REACTOME
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04540
Gap junction pathway
hsa04740
Olfactory transduction pathway
hsa04730
Long-term depression pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04970
Salivary secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt Q13976
TrEMBL B1ALS0 Q5JP05 Q5SQU3
UniProt Splice Variant
Entrez Gene 5592
UniGene Hs.407535 Hs.641130
RefSeq NM_001098512 NM_006258 XM_005269971 XM_005269972
HUGO HGNC:9414
OMIM 138670 176894
CCDS CCDS7244
HPRD
IMGT
EMBL AC009986 AC022025 AC022537 AC026228 AC027118 AC068062 AC069079 AC073584 AK093436 AL157399 AL391378 AL596105 AL607031 AL731537 AL928686 BC062688 BC127090 CH471083 D45864 Y07512 Z92867 Z92868 Z92869 Z92870 Z92871 Z92872 Z92873 Z92874 Z92875 Z92876 Z92877 Z92878 Z92879 Z92880 Z92881 Z92882 Z92883 Z92884 Z92885
GenPept AAH62688 AAI27091 BAA08297 BAG52715 CAA68810 CAB07436 CAB07437 CAI17115 CAI39626 CAI40743 CAI41305 EAW54140
RNA Seq Atlas 5592

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca