InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRKG1

Summary

InnateDB Gene

IDBG-637097.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKG1

Gene Name

cGMP-dependent protein kinase 1

Synonyms

cGK 1; CGKI; cGKI-beta

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018404

Encoded Proteins

IDBP-689094

cGMP-dependent protein kinase 1

IDBP-689096

cGMP-dependent protein kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185532:
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:6906081-8343629

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024490	ENSBTAP00000024490
ENSBTAT00000030539	ENSBTAP00000030518

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004692	cGMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030553	cGMP binding

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0016358	dendrite development
GO:0019934	cGMP-mediated signaling
GO:0030900	forebrain development
GO:0043087	regulation of GTPase activity
GO:0045986	negative regulation of smooth muscle contraction
GO:0060087	relaxation of vascular smooth muscle
GO:0090331	negative regulation of platelet aggregation