Version 5.4
Homo sapiens Gene: SLC7A3
Summary
InnateDB Gene IDBG-74707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC7A3
Gene Name solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165349
Encoded Proteins
IDBP-74709
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
IDBP-74711
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:70925582-70931125
Strand Reverse strand
Band q13.1
Transcripts
ENST00000374299 ENSP00000363417
ENST00000298085 ENSP00000298085
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
GO:0015181 arginine transmembrane transporter activity
GO:0015189 L-lysine transmembrane transporter activity
GO:0015326 cationic amino acid transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006810 transport
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0015809 arginine transport
GO:0015819 lysine transport
GO:0055085 transmembrane transport
GO:1902475 L-alpha-amino acid transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031297
View Gene Order
ENSBTAG00000007403
Not yet available
Pathways
NETPATH
REACTOME
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8WY07
TrEMBL
UniProt Splice Variant
Entrez Gene 84889
UniGene Hs.175220
RefSeq NM_001048164 NM_032803
HUGO HGNC:11061
OMIM 300443
CCDS CCDS14404
HPRD
IMGT
EMBL AF320612 AK027447 AK074865 AK075014 AL627071 BC033816 CH471132
GenPept AAH33816 AAL37184 BAB55118 BAC11253 BAC11353 CAI40156 EAX05329 EAX05330
RNA Seq Atlas 84889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca