InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC7A3

Summary

InnateDB Protein

IDBP-74709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A3

Protein Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363417

InnateDB Gene

IDBG-74707 (SLC7A3)

Protein Structure

UniProt Annotation

Function

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. {ECO:0000269PubMed:11591158}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala. {ECO:0000269PubMed:11591158}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity
GO:0015181	arginine transmembrane transporter activity
GO:0015189	L-lysine transmembrane transporter activity
GO:0015326	cationic amino acid transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0015809	arginine transport
GO:0015819	lysine transport
GO:0055085	transmembrane transport
GO:1902475	L-alpha-amino acid transmembrane transport