Version 5.4
Homo sapiens Gene: IPMK
Summary
InnateDB Gene IDBG-74863.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IPMK
Gene Name inositol polyphosphate multikinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151151
Encoded Proteins
IDBP-74865
inositol polyphosphate multikinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:58191517-58267934
Strand Reverse strand
Band q21.1
Transcripts
ENST00000373935 ENSP00000363046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 inositol tetrakisphosphate 3-kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
Biological Process
GO:0001841 neural tube formation
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060733
View Gene Order
ENSBTAG00000011197
Not yet available
Pathways
NETPATH
REACTOME
REACT_150275
Synthesis of IPs in the nucleus pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt Q8NFU5
TrEMBL
UniProt Splice Variant
Entrez Gene 253430
UniGene Hs.30280
RefSeq NM_152230
HUGO HGNC:20739
OMIM 609851
CCDS CCDS7250
HPRD 17153
IMGT
EMBL AF432853 BC065709 BK000580
GenPept AAH65709 AAM97838 DAA01362
RNA Seq Atlas 253430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca