InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IPMK

Summary

InnateDB Protein

IDBP-74865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IPMK

Protein Name

inositol polyphosphate multikinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363046

InnateDB Gene

IDBG-74863 (IPMK)

Protein Structure

UniProt Annotation

Function

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). {ECO:0000269PubMed:12027805, ECO:0000269PubMed:12223481}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12027805}.

Disease Associations

Tissue Specificity

Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon. {ECO:0000269PubMed:12223481}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000823	inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824	inositol tetrakisphosphate 3-kinase activity
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity

Biological Process

GO:0001841	neural tube formation
GO:0016310	phosphorylation
GO:0032958	inositol phosphate biosynthetic process
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process