Version 5.4
Homo sapiens Gene: GAS1
Summary
InnateDB Gene IDBG-74874.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS1
Gene Name growth arrest-specific 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000180447
Encoded Proteins
IDBP-74876
growth arrest-specific 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:86944363-86947189
Strand Reverse strand
Band q21.33
Transcripts
ENST00000298743 ENSP00000298743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0007050 cell cycle arrest
GO:0007411 axon guidance
GO:0008284 positive regulation of cell proliferation
GO:0008589 regulation of smoothened signaling pathway
GO:0009953 dorsal/ventral pattern formation
GO:0010955 negative regulation of protein processing
GO:0012501 programmed cell death
GO:0021587 cerebellum morphogenesis
GO:0021904 dorsal/ventral neural tube patterning
GO:0030308 negative regulation of cell growth
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0042473 outer ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0042476 odontogenesis
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0045165 cell fate commitment
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045930 negative regulation of mitotic cell cycle
GO:0048589 developmental growth
GO:0048592 eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048706 embryonic skeletal system development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060021 palate development
GO:0060628 regulation of ER to Golgi vesicle-mediated transport
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0046658 anchored component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052957
View Gene Order
ENSBTAG00000046803
Not yet available
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
KEGG
hsa04340
Hedgehog signaling pathway pathway
INOH
PID NCI
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.65029
RefSeq NM_002048
HUGO
OMIM
CCDS CCDS6674
HPRD 00747
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca