InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAS1

Summary

InnateDB Protein

IDBP-74876.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAS1

Protein Name

growth arrest-specific 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298743

InnateDB Gene

IDBG-74874 (GAS1)

Protein Structure

UniProt Annotation

Function

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. {ECO:0000269PubMed:8127893}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007050	cell cycle arrest
GO:0007411	axon guidance
GO:0008284	positive regulation of cell proliferation
GO:0008589	regulation of smoothened signaling pathway
GO:0009953	dorsal/ventral pattern formation
GO:0010955	negative regulation of protein processing
GO:0012501	programmed cell death
GO:0021587	cerebellum morphogenesis
GO:0021904	dorsal/ventral neural tube patterning
GO:0030308	negative regulation of cell growth
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0042476	odontogenesis
GO:0042733	embryonic digit morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045930	negative regulation of mitotic cell cycle
GO:0048589	developmental growth
GO:0048592	eye morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048706	embryonic skeletal system development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060021	palate development
GO:0060628	regulation of ER to Golgi vesicle-mediated transport
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand